Atletico Madrid maintained a two-point lead in La Liga with a 3-0 victory at Las Palmas and Barcelona and Real Madrid stayed hard on their heels with thumping wins over Athletic Bilbao and Sporting Gijon on Sunday.
Brazilian defender Filipe Luis scored for the second game running as Atletico Madrid beat Real Sociedad 1-0 on Tuesday to rack up a fifth straight win in La Liga and provisionally consolidate third place in the standings.
Images from Sunday's action in La Liga and Ligue 1.
Iniesta has spent all of his senior career at Barcelona and is their most decorated player ever along with Lionel Messi, having lifted 31 trophies, which is soon to be 32 if Barca clinch the Liga title on Sunday at Deportivo La Coruna.
An early own goal by Luke Shaw, who deflected in a header from Luis Suarez, decided a tight first leg and gave Barca their first victory at Old Trafford in five attempts in European competition.
Real Madrid can bury Atletico's hopes of winning La Liga with a third straight victory against their city neighbours on Sunday that would leave the capital's second club trailing by six points.
Cristiano Ronaldo missed a penalty as Real Madrid and neighbours Atletico were held to draws leaving Barcelona with an eight-point lead at the top of La Liga and 13 matches left.
Piotr Zielinski converted two penalties for Inter Milan as they played out a thrilling 4-4 draw with Juventus.
David Villa struck twice to lead Barcelona to a 5-0 rout of Real Madrid on Monday with a scintillating performance which put the champions two points clear of their arch-rivals at the top of the Spanish La Liga.
Barcelona eased into the King's Cup last 16 when goals from Pedro, Cristian Tello and Neymar secured a 3-0 second-leg victory at home to third-tier Cartagena on Tuesday for a 7-1 aggregate success.
Real Madrid overcame an early howler from Sergio Ramos to beat Real Sociedad 3-1 at home on an eventful Saturday at the Santiago Bernabeu, where Gareth Bale was loudly booed by his own supporters and Luka Modric returned to his very best form.
Barcelona's 16-year-old forward Ansu Fati continued his explosive start to life in the first team by scoring and providing an assist as the La Liga champions thrashed Valencia 5-2 on Saturday.
Gerard Pique has been caught on camera apparently telling Spain coach Vicente del Bosque that Barcelona team mate Cesc Fabregas is poised to leave the La Liga side.
Barcelona snapped a four-match winless run in La Liga with a 4-2 home victory over title rivals Sevilla on Saturday to reclaim top spot but the triumph was marred by talisman Lionel Messi fracturing his arm and being ruled out for three weeks.
Coutinho, who arrived from Liverpool for a club record 165 million euros ($185.18 million) in January 2018, has so far shown little to suggest he will be able to compensate for Frenchman Ousmane Dembele's absence against Lyon in the UEFA Champions League tie.
As well as putting Barcelona a step closer to winning La Liga, Saturday's 1-0 home win over Levante showed that defender Eric Abidal is fit enough to play a full match after making a remarkable recovery from a liver transplant.
Barcelona cranked up the pressure on Real Madrid by moving seven points clear at the top of La Liga on Saturday after sweeping aside Racing Santander 3-0 at the Nou Camp.
Unbeaten leaders Barcelona extended their near-perfect start but again suffered the defensive lapses that have plagued them this season when Lionel Messi netted twice in a 4-2 La Liga win at Real Mallorca on Sunday.
Barcelona earned their first Primera Liga win of the season with a 6-1 rout away to promoted Sporting Gijon on Sunday.
Zlatan Ibrahimovic came off the bench to volley 10-man Barcelona to a 1-0 home victory over Real Madrid on Sunday which put them back on top of La Liga.
Seemingly rudderless and leaderless, Barcelona have little time to find solutions to their dip in form but they have a chance to lift morale when they visit a distracted Real Madrid in La Liga on Saturday.
Key head-to-head battles in Saturday's "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT)
'It has been good on pitch and off pitch,' Lampard said.
A weakened Real Madrid team routed Valencia 6-3 away on Saturday while an uninspiring 2-0 win for Barcelona at home to lowly Osasuna maintained their eight-point lead at the top of La Liga.
Barcelona will ignore attempts by Real Madrid coach Jose Mourinho to play mind games, according to Lionel Messi.
Saturday marks the 10th anniversary of Lionel Messi's first-team debut with Barcelona, when the Argentine came on as a 16-year-old substitute during a friendly against Porto in Portugal.
Brazil forward Neymar will sign a new five-year contract with Barcelona on Friday, the La Liga champions said on Monday.
Barcelona forward David Villa has been admitted to hospital due to a bout of renal colic and may be unavailable for Saturday's league game at Granada, the La Liga leaders said on Monday.
Primera Liga leaders Barcelona produced a sparkling display of fluent, attacking football to outclass arch-rivals Real Madrid.
Bayern Munich thrashed Bayer Leverkusen 5-1, while Barcelona came from behind to beat Valencia 3-1 in LaLiga at Camp Nou on Sunday.
Barcelona coach Pep Guardiola refused to look for excuses after the La Liga champions were humbled 2-0 at home by promoted Hercules on Saturday.
Barcelona have won the Champions League five times, most recently in 2015, and face a tough task to get back to the top table of European football after being forced to sell club legend Lionel Messi due to financial problems.
Spanish media predicted the end of the Primera Liga title race on Monday after leaders Real Madrid went eight points clear of Barcelona at the weekend.
Eric Abidal crowned a superb defensive display with a rare goal to help Barcelona to a 1-1 draw at Athletic Bilbao on Wednesday and put the La Liga leaders through to the quarter-finals of the King's Cup on away goals.
News of all that's transpired on and off the football field
Real Madrid forward Gareth Bale lashed home to deny La Liga champions Barcelona victory in an ill-tempered 'Clasico' which finished 2-2.
Thierry Henry scored a hat-trick to steer Barcelona to a 4-1 win at bottom club Levante in the Primera Liga on Saturday.
Karim Benzema made history at Real Madrid, the battle for the top four continues to heat up
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